March 31, 2012
New Breakthrough Biotech Discovery
How a California biotech company is researching cures for Parkinson’s Disease, diabetes, blindness — even wrinkles!
In this issue…
- Stem cells: The defining miracle of the 21st century?
- Biotech scientists make new discovery for rejuvenating aging skin —
- Much more
In late 2007, something incredible happened
In Carlsbad, California, a team of the world’s foremost biotech scientists discovered a way to grow new healthy tissues (possibly even whole organs) to replace damaged ones — without destroying human embryos.
Their revolutionary stem cell discovery was about to wash over the entire world. I think it will forever change the face of healthcare.
By John Mauldin
Long-time readers know that I have recently started researching and investing in small biotech stocks.
I periodically talk with CEOs and scientists about bleeding-edge research that promises profound changes in our lives over the coming years. It is one of the reasons I remain optimistic, even in our deleveraging Muddle Through Economy. No one in 2022 is going to want to go back to the good old days of 2012 health care.
In the process of my research I have come across an amazing accidental discovery, which I am going to share with you. As with all such fortuitous events, there is a story, and this is a fun one. But it starts with what sparked my personal interest.
Here’s a small confession. Maybe you can relate. I actually think that vanity, in a healthy dose, can be a good thing. It’s vanity and a desire to keep going for a long time (at 87, Richard Russell is my hero) that keeps me in the gym wrestling with weights and slugging along on the treadmill, and it’s vanity (and the desire to stay healthy) that stops me from grabbing a second cookie or another handful of peanuts, when I know full well where they will end up — somewhere unwanted.
Warning: while I am going to tell you about a very interesting (even exciting) company, this can be considered marketing material, not what is usually associated with my writings. For some of my readers it will open you up to a whole new world. (Think investing in yourself, think image, think self-esteem and outright physical attractiveness.) Here’s the scoop:
As Outside the Box readers know, I have become good friends with Pat Cox, the writer of Breakthrough Technology Alert. We both love new, cutting-edge tech, especially biotech, and we probably talk at length once a week. About two years ago ago he shared with me an (at the time) unbelievable story about International Stem Cell Corporation (ISCO), a company that he had previously written about in his letter and in which I had purchased a few shares. They have an impressive portfolio of stem cell patents that gives them a very solid position in the growth of the stem cell world.
Pat told me about a remarkable, proprietary cream that the scientists at ISCO had sent him. It was derived from the ultra-expensive nutrient emulsion that they used to actually grow skin with stem cell proteins.
Pat’s mid-50s wife put it on her face, and he raved about the results. “She looks so much younger, it’s hard to believe!” I remember smiling and thinking skeptical thoughts. Pat can be very enthusiastic sometimes.
About a month later, Pat arranged for me to meet Ken Aldrich, the chairman of ISCO, in San Diego. I toured their high-tech facility—blew me away—where I saw them actually growing corneas that looked like tiny floating jellyfish in test tubes. They grow corneas to use in place of rabbits for skin product testing. Those corneas are soon scheduled to be used for human cornea transplants in India. In other labs they are growing neuronal (brain) cells for the treatment of neurodegenerative conditions like Parkinson’s disease. Throughout the labs I saw really cool stuff, way beyond most of our imaginations!
Early on, Ken wanted to develop some revenue streams to fund the business (because the FDA approval process takes years) so they would not have to go to the highly dilutive venture community. As do all small biotechs, they have a high capital “burn rate” that threatens to dilute their investment if they can’t quickly produce positive cash flow. So they created a division that sells various mediums in which to grow all sorts of cells.
Long story short, in the process of making the “medium” for skin cell growth, they discovered that the skin cells actually grow much better and look “healthier” in the new medium. This new medium contained standard minerals and vitamins but—and this is the key thing—it was also the medium in which actual stem cells were growing. And the stem cells changed the medium, since (and this is way cool) cells actually communicate with other cells using messaging molecules, which are proteins. First one and then more of the scientists could not resist putting the medium with the skin stem cell messaging molecules on their faces and hands. Just curious, don’t you know? I mean, they ARE scientists.
And yes, over time it made an impressive difference in the look, feel, and texture of their skin. But there was a problem. The stem cell proteins that were in the growth medium were still proteins, and that meant they would decay in a short time. So the medium had to be kept refrigerated to remain viable, and was therefore not something that was commercially viable.
The scientists using the cream, and the handful of other people who tried out the early version, like Pat’s wife, knew they were on to something more than a little interesting here. Another long story short, they came up with two solutions. One, they started using a technique from a Japanese nanotechnology firm that enabled them to encapsulate the proteins from stem cell extract inside a nanovessicle in order to keep them stable and give them the ability to penetrate the upper layer of the skin, and then they figured out how to “blow up” the cells in order to harvest the other 90% of the messaging proteins. That is very important, because cultivating stem cells is not easy—it takes time, some very expensive equipment, and cleanrooms. The cells are cultured in numerous batches, because if a batch goes bad it must be thrown out.
When they had figured out the hard part, then they had to learn how to create a serum that would let their stem cell extract work on faces. They brought in the best consultants they could find to help them use state of the art skin-cream technology, and then configured it to work with their extract full of stem cell proteins.
And then they started rigorously, indefatigably testing it to get the right mix that produced just the effect they wanted. They conducted all official safety and efficacy tests according to the highest FDA standards, with independent laboratories and physicians. They confirmed the following anti-aging claims: moisture effect, increased skin elasticity, sun protection, decreased fine lines and wrinkles, improved skin tone. They started letting friends use it, all in strict secrecy, and as luck would have it I got chosen (or actually, I begged Ken) to try out some of the early samples. Bottom line: I and my kids could see a real difference in my face.
Let’s take a moment to learn more about some of this “miracle” (to me at least) stem cell therapy for skin.
They extracted growth factors, amino acids, peptides and enzymes from the stem cells, encapsulated them into bi-layer nanospheres that preserved the stability of the ingredients and ensured that they could penetrate the skin. Proteins are notoriously unstable, so the bi-layer gave it added protection. A lot of skincare products contain peptides that are too large to penetrate the skin, so they sit on the surface—almost like they are sitting on the sidelines--and have little to no value. Lifeline’s delivery system therefore (1) ensures the stability of the stem cell extracts and (2) enhances penetration. Once the stem cell extracts are absorbed by the skin, they can activate certain biological processes within the skin cell—by sending molecular messages to increase the activity of genes responsible for collagen and elastin production and cellular proliferation.
It’s these stem cell extracts that are the “heroes” of the skin creams, but the scientists also added vitamins and anti-oxidants for added protection. CoQ-10, for example, is naturally produced by the skin, and helps defend the skin against free radicals. But as we age, CoEnzyme Q 10 supply diminishes. By adding some to the cream, the supply is replenished and your skin is better able to protect against free radical damage.
All of these stem cell extracts and added nutrients stimulate the skin’s ability to protect and renew itself, replace damaged collagen fibers with new ones—and cause a proliferation of healthy skin cells.
The Skin Serum Just Works!
It took about 60 days for me to see a difference. But I can tell you personally that it works, I see it in my own face and the people that have used it. I use it every time I shower.
Now, when I travel, which is all too frequently, I get told that I don’t look my age. People ask me, “what is your secret?” Quite frankly, I don’t have any. I’ve learned to limit myself to one handful of peanuts; I head to the gym several times a week, and for more than a year I’ve used Lifeline Skin Care, which has rejuvenated my skin.
I now have hundreds of readers who have used the crèmes. I hear from them as they write or come up and talk to me wherever I go. Those who, like me use it consistently, love the new look and feel of their skin. It’s because of their feedback and results that I am once again mentioning the company.
Here's what other people are saying about Lifeline Skin Care:
I Get Compliments on a Regular Basis!
As a plastic surgeon, patients check out my skin all day long. I had some brown spots so I was planning to give myself a peel. However with Lifeline and my usual Retin-A, after 4 weeks the brown spots were significantly reduced. I can't remember the last time someone had anything nice to say about my skin. But since I started using Lifeline three months ago, at least six people have complimented me. Lifeline is the cutting-edge in anti-aging science.
-- Paul Chasan, MD,
Ranch and Coast Plastic Surgery, Del Mar, California
I Don't Leave Home without It!
I just came back from six weeks in Europe, and didn't take Lifeline with me because I didn't want to bother with it. What a mistake! I noticed a big difference in my skin (and it wasn't positive!) I came back with great memories but horrible wrinkles.
-- Barb, Collegeville, PA
I Beat Cancer, and I Beat the Wrinkles Too!
I'm a cancer survivor, but many long months of radiation and chemotherapy wore out my skin. My wrinkles and skin laxity were much worse than others my age. When my doctor recommended Lifeline, I tried the nighttime product, and the improvement in my skin has been quite remarkable. Many of my friends have noticed -- and for years, I tried everything -- well, just about everything! I'm very happy to look in the mirror and see the improvement.
-- Susan M, El Paso, TX
Lifeline is hands down the best skin-care regimen I have ever tried. It doesn't take much to make a difference but you have to stick with it. It took about a month before I saw any visible results, but then my friends starting asking, "Wow, what are you using on your skin?"
-- Linja, La Jolla, CA
Wow, Wow, Wow!!
Normally when I buy something new my girlfriend will say "wow". But I started using Lifeline while on a business trip to Asia, and when I came home she said "wow, wow, wow! You look great!" Not sure if it was because I had been away for three weeks or just because my skin looked great. Whatever… I'll take the compliment -- and all of the "wow's" I can get.
-- Brian K, Rancho Palos Verdes, CA
Since I started using Lifeline my skin feels much healthier, and the oiliness has subsided. Best of all, I have not had any breakouts for several weeks. I really appreciate the moisturization, but best of all is that my skin looks so much more radiant than ever before.
-- Alica, Sausalito, CA
Thank You, Mom; Thank You, Lifeline!
I have never had any real skin problems (thank you, Mom!), but since I turned 40, stress, lack of sleep, and life-in-general have taken a toll on my skin. I ordered both products, and immediately my skin felt "re-awakened."
-- Miss B, Hoboken, NJ
We've Been Around Long Enough to Know that This is the Real Thing!
The results that I have experienced with Lifeline have been nothing less than amazing. I'm amazed. My husband is amazed too -- both with my skin and his own. We got started in December 2010, and within about 6 weeks the vertical lines around my mouth were GONE! Nothing has ever worked there before.
-- Carol F, Santa Monica, CA
I first told some of my readers about Lifeline Skin Care about 16 months ago. A lot has changed since then.
Here’s an update:
- Lifeline has been named an anti-aging breakthrough by NBC, CBS, ABC, Fox, etc in Miami, Phoenix, San Diego, Chicago, Cincinnati, and Atlanta—to name a few.
- International Stem Cell has published the results of some clinical studies proving the efficacy of the products. These are actual results based on instrumentation—not perception. They used ultra-sensitive instrumentation and digital skin analyzers.
The regimen included daily use of Lifeline Defense Day Moisture Serum and Recovery Night Moisture Serum.
And here were the results:
- Skin Hydration by Corneometer. 93.3% demonstrated a statistically significant improvement in skin hydration
- Skin Elasticity by Cutometer. 73.3% showed improvement in skin elasticity
- Skin Brightness by Chromameter. 63.3% showed improvement in skin brightness.
- Appearance of Fine Lines and Coarse Wrinkles. 66.6% reported significant improvement
Lifeline Skin Care is a bit different than most skincare companies that are staffed by a small (or even large!) army of sales and marketing people. This company is science-based—and that mindset creates a different approach to both product development and clinical substantiation. Lifeline also conducted laboratory experiments to determine what effect, if any, the stem cell extracts have on the expression level of genes that are responsible for skin firmness, elasticity and wrinkles. Particularly, they studied elastin, two different types of collagen, epidermal growth factors, keratinocyte growth factors and fibroblast growth factors.
Skin samples were taken from subjects and fibroblast cells isolated and cultured from these samples. The fibroblasts were then treated with the Lifeline stem cell extracts and then gene expression levels were measured. Here were the results:
Lifeline is now offered by selected dermatologists, plastic surgeons and some major spas throughout the country. These resorts are all nice places and gorgeous properties. But you don’t need to travel there to get Lifeline.
Since I wrote previously, the company has begun offering the products internationally. If you live in Australia/New Zealand, go to stemcellskinscience.com.au/mauldin. Note the Australian site is available only for people who live “down under.”
How You Can Get Started
Are you ready to try this revolutionary skin care treatment? Here’s my advice:
The serum seems to work better on mature skin.
- If you’re 22, and you’re young and healthy, sun protection is the most important thing you can do for your skin. Don’t spend your money on stem cell skin care. Pay off your college loans first!
- If you’re 30-plus and cellular activity has begun to slow, you’re right at that turning point when you should consider the product.
- If you’re 40 or 50-plus, now is the time to get started. I think you’ll definitely see a result. Stick with it, though. This is not the stuff you see advertised on infomercials. It’s the real deal. You need to plan to use it regularly for at least 2 to 3 months. That’s the way that skin rejuvenation and restoration works. I now use the night time crème after I shower.
Lifeline has a Day Serum and a Night Serum, both priced in line with most high-end crèmes, $190 for the Night Serum and $160 for the Day Serum, which has a broad spectrum SPF 15. I personally urge you to initially try out both in a disciplined daily/nightly regimen as was used in the clinical studies. The ingredients are NOT cheap, but they are real products from one of the top biotech engineering labs in the world. I have persuaded Lifeline to offer the combination of both the day and night serum together as it works better when you use both, and I asked them to give my readers a , which is available only for a limited time.
While this may sound like a bit of a cliché, the truth is that if we look better, we feel better; and if we feel better, we perform better. This cream has made a big difference for me. I am told I look ten years younger and that makes me feel great. Yes, I will continue to watch my diet and go to the gym. But using Lifeline Skin Care is much easier than either of those.
If you are looking for the same or a similar result, then I suggest you to get some for yourself.
Yours for younger looking skin,
P.S. I’ve asked the company to do a better job of keeping up with demand, and they’re working to ensure inventory. That being said, I cannot guarantee that inventory will be immediately available, so I urge you to order soon.
International Stem Cell Corporation is a leader in stem cell research—using its proprietary pluripotent parthenogenetic stem cells to treat incurable diseases. From a single stem cell line the company has the potential to provide tissue that matches millions of people.
The future is both exciting and challenging. But the results are immediately rewarding—in the laboratory, in the clinic, and now, at home.
I take pleasure in recommending Lifeline Skin Care to you, knowing that revenues from this cosmeceutical product will help bring life-saving therapies to market that much quicker.