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How We Stabilize Stem Cell Growth Factors in Lifeline Stem Cells Skin Care

Scientists and medical professionals have known for years that growth factors and proteins help visibly rejuvenate skin. It works in the laboratory. It works in the petri dish. Now, make it work on your skin.

According to Ruslan Semechkin, PhD, Chief Scientific Officer of International Stem Cell Corporation, “Delivering human growth factors from the laboratory to the skin is a giant leap of time, distance, chemistry and biology. More than that, it's a big leap of technology.” International Stem Cell Corporation is the parent company of Lifeline Skin Care, which makes stem cell derived creams based on human, non-embryonic stem cells. The proteins, peptides and growth factors are separated from the solids of the stem cells (the cell membrane, organelles, nucleus and DNA), so that they can be added to the anti-aging skin care creams.

Lifeline Skin Care Day and Night Serums

But the problem is this: human-derived proteins are very fragile. They would quickly degenerate in a topical serum or lotion if they were exposed to the real world--oxidation, water or excessive heat. So the proteins need to be sheltered and preserved so they stay fresh in the bottle.

Then there’s a second problem: delivering them to the skin. Skin is intended as a barrier to protect our bodies from external insult or injury. It works to keep things out — and not allow things to penetrate. But topical creams have limited value if they only remain on the surface of the skin, which is comprised mostly of dead skin cells.

Peptides Encapsulated Inside Nanospheres

The challenge, then, is to protect and preserve the growth factors, peptides and proteins so they can be delivered from the laboratory to the skin. Until fairly recently, offering human-derived ingredients in skin care formulations couldn’t be done. The growth factors couldn’t possibly maintain their activity or their potency. But new nanotechnology, called microencapsulation, encases ingredients in a shell,called a microcapsule. There are different kinds of microcapsules — they can be released all at once (if pressure has been applied or if it dissolves), or they can be gradually time-released. This technology is not unique to skin care, it’s also commonly used in: food (such as chewing gum with sudden bursts of flavor); pharmaceuticals (for time-release properties of antihistamines or painkillers), shower gel and shampoo.

In order for the stem cell growth factors to remain stable, the microcapsule has to protect the contents in the creams. Water is good for our bodies, but not for ingredients, because it can lead to rapid oxidation and reduced effectiveness. Since Lifeline creams and serums are water-based, the microsphere excludes water from the environment around the proteins, thus protecting them.

International Stem Cell Corporation produces these microcapsules of stem cell growth factors by ultrasonicating a mixture of fatty acids and surfactants with the purified stem cell extract.

Lifeline uses only airless bottles — another relatively new concept in skin care, that uses rigid bottles that protect the contents from the contamination of air, dust, fingers, etc. Unlike traditional pumps that use a dip tube, airless packages have a diaphragm that moves up the bottle and evacuates the product in measured doses. Not only does airless packaging protect the contents, it results in almost zero waste, as the contents can be completely dispensed. Unopened, the shelf life of Lifeline stem cells skin care products have been successfully tested for at least two years (the Recovery Night Moisture Serum has been successfully tested to have three years stability), though it is recommended that the products be used within six months after opening.

Finally, the products are ready to be dispensed at home. When applied to the skin, the microspheres penetrate the skin, their lipid shell ruptures, releasing the growth factors so they can begin to make skin look younger and more radiant. And technology has moved from the lab to your skin.